The division's countries of deployment are Mozambique and Tanzania. In addition it is responsible for the following three regional programmes:
- Great Lakes (Rwanda, Burundi, Democratic Republic of the Congo)
- Horn of Africa (Somalia, Ethiopia, Kenya)
- Southern Africa (with focal points in Zimbabwe, Malawi, Zambia, Lesotho and Swaziland)
ESA is active in healthcare, rural development and employment, transition and good governance. It coordinates its programmes with the other sections of the FDFA active in these countries/regions, in particular with the following divisions of the Directorate of Political Affairs: the Human Security Division (HSD) in the area of peacebuilding and the Sub-Saharan Africa and Francophonie Division (SAFD).